Once the Red River, the Cane River is now an oxbow lake surrounded by lush farmland and historic landmarks. The Cane River National Heritage Trail Scenic Byway starts in Natchitoches, Louisiana’s oldest permanent settlement, known for its historic district. Visitors can explore charming antique shops, cafés, and historic homes, including the Prudhomme-Rouquier House, built with the unique bousillage technique. The trail follows the river southward, passing Fort St. Jean Baptiste and offering picturesque views of plantations, magnolias, and live oaks.

Further down the trail, visitors encounter Natchez, home to the Cane River Creole National Historical Park, which preserves both grand plantation homes and the daily life of enslaved workers. Melrose Plantation, built by the family of freed slave Marie Therese Coincoin, became a center of Creole culture and was later home to self-taught artist Clementine Hunter. The trail concludes in Cloutierville, a small historic town with remnants of its plantation-era economy, including St. John’s Catholic Church and tenant houses from the late 19th century.

Throughout its route, the trail showcases the deep cultural and historical roots of Louisiana’s Cane River region.